Cell-penetrating Peptides as Versatile Vehicles for Oligonucleotide Delivery
نویسندگان
چکیده
منابع مشابه
Rational modifications of cell-penetrating peptides for drug delivery Applications in tumor targeting and oligonucleotide delivery
High molecular weight biomolecules are becoming increasingly important in the development of new therapeutics. However, the hydrophilic nature and size of such molecules creates a major limitation for their application – poor penetration through biological membranes. Over a decade ago, a new class of peptides, cell-penetrating peptides (CPPs), with membrane translocating ability, was discovered...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2012
ISSN: 1525-0016
DOI: 10.1038/mt.2011.284